Prof. Anita R. Maguire
Department of Chemistry
University College Cork
Tel. (secretary) +353-21-4902167
Fax. +353-(0)21-4274097 (Departmental Office)
1985 B.Sc. (1st Hons.) at University College Cork
1989 Ph.D. at University College Cork (Prof. M.A. McKervey)
1989 Postdoctoral Associate, Facultes Universitaires, Namur, Belgium (Prof. A. Krief)
1990 Postdoctoral Fellow, University of Exeter, UK (Prof. S.M. Roberts)
1991 College Lecturer in Organic Chemistry, University College Cork
1998 Director, B.Sc. programme in The Chemistry of Pharmaceutical Compounds
2002 Director, Analytical and Biological Chemistry Research Facility
2002 Associate Professor of
Organic Chemistry, University College Cork
2004 Professor of Pharmaceutical Chemistry
Research Interests and Activities
Link to Organic and Pharmaceutical Synthesis Research Team page
· Novel synthetic methodology
- including the use of a-diazocarbonyl compounds and organosulfur compounds in synthesis
· Asymmetric synthesis
- including asymmetric catalysis and application of biotransformations in organic synthesis
· Synthesis of biologically active compounds
- current projects are targeted towards compounds with anti-viral and anti-cancer activity
· Extensive interaction with the pharmaceutical industry, within Ireland and overseas
· Member of National Research Support Fund Board from Jan.1999-Dec. 2001.
· Member of ICSTI from September 2000.
Chairman, ICSTI Task Force on Embedding the PharmaChem Sector in Ireland 2001-3.
· Member of IRCSET from June 2001.
· Vice Chairman (1998- 1999), Chairman (1999-2000) of the EU COST (European Co-operation in the Field of Scientific and Technical Research) Management Committee for Action D12 concerning "Organic Transformations: Selective Processes and Asymmetric Catalysis".
Vice Chairman (2001 to date) D24 “Sustainable Chemical Processes: Stereoselective Transition Metal-Catalysed Reactions”.
Member of Management Committee (2002 to date) D28 “Natural Products as a Source for Discovery , Synthesis and Application of New Pharmaceuticals”.
· Member of the Forfas Technology Foresight Chemical and Pharmaceutical Panel (1998).
Excellent Stereocontrol in
Intramolecular Buchner Cyclisations and Subsequent Cycloadditions;
Construction of Polycyclic Systems.
A.R. Maguire, N.R. Buckley, P. O’Leary, and G. Ferguson, Chem. Commun., 1996, 2595-6.
Asymmetric Reduction of 1-Methylsulfonylalkan-2-ones with Baker's Yeast.
A.R. Maguire and D.G. Lowney, J. Chem. Soc., Perkin Trans. 1, 1997, 235 - 8.
Selective Manganese-Mediated Transformations Using the Combination : KMnO4 / Me3SiCl.
I.E. Marko, P.R. Richardson, M. Bailey, A.R. Maguire and N. Coughlan, Tetrahedron Lett., 1997, 38, 2339-42.
Enantioselective Introduction of a
Benzenesulfonylmethyl Substituent at an Unactivated Carbon Atom via
A.R. Maguire and L.L. Kelleher, Tetrahedron Lett., 1997, 38, 7459 - 62.
Synthesis of a-Diazo-b-Oxo Sulfoxides
A.R. Maguire, P.G. Kelleher, G. Ferguson, and J.F. Gallagher, Tetrahedron Lett., 1998, 39, 2819-22.
Rhodium Catalysed Decomposition of a-Diazosulfoxides : Formation of a-Oxo Sulfines as Intermediates
A.R. Maguire, P.G. Kelleher and S.E. Lawrence, Tetrahedron Lett., 1998, 39, 3849-52.
Stereocontrol in the Intramolecular Buchner Reaction of Diazoketones
A.R. Maguire, N.R. Buckley, P. O’Leary, and G. Ferguson, J. Chem. Soc., Perkin Trans. 1 , 1998, 4077-91.
Dynamic Kinetic Resolution in the Baker's Yeast Mediated Reduction of 2-Benzenesulfonylcycloalkanones
A.R. Maguire and N. O'Riordan, Tetrahedron Lett., 1999, 40, 9285-8.
Matrix Isolation and Photochemistry of a-Diazo Sulfoxides: Formation of an a-Oxo Sulfine as an Intermediate
W. Sander, A. Strehl, A.R. Maguire, S. Collins, and P.G. Kelleher, Eur. J. Org. Chem., 2000, 3329-3335.
Synthesis of Indomethacin Analogues for Evaluation as Moderators of MRP Activity
A.R. Maguire, S.J. Plunkett, S. Papot, M. Clynes, R. O’Connor and S. Touhey, Biorg. Med. Chem., 2001, 9, 745-762.
Enantioselective Synthesis of Sulindac
A.R. Maguire, S. Papot, A. Ford, S. Touhey, R. O’Connor, and M. Clynes, Synlett, 2001, 41-4.
4-Ethynyl-1,2-methylenedioxybenzene at 150K
S.E. Lawrence, A.J. Blake, A.R. Maguire, and E.J.A. Moynihan, Acta Cryst C, 2001, 412-413.
Dynamic Equilibria in
the Products of Intramolecular Buchner Additions of Diazoketones to Aryl Rings
Anita R. Maguire,
Patrick O'Leary, Francis Harrington, Simon E. Lawrence
and Alexander J. Blake, J. Org. Chem.,
2001, 66, 7166-7177.
New Methods for the Synthesis of N-Benzoylated Uridine and Thymidine Derivatives
Anita R. Maguire, Isabelle Hladezuk and Alan Ford, Carbohydrate Research, 2002, 337(4), 369-372.
Relationship of Indomethacin Analogues for MRP-1, COX-1 and COX-2
Inhibition; Identification of
Novel Chemotherapeutic Drug Resistance Modulators
S. Touhey, R. O’ Connor, S.J. Plunkett, A.R. Maguire and M. Clynes, Eur. J. Cancer, 2002, 38(12), 1661-70.
Chemoenzymatic methods in the asymmetric synthesis of α-diazosulfoxides
Maguire, Stuart G. Collins and Alan Ford, ARKIVOC, 2003, Part (vii), 96-109.
B.Sc. in Chemistry of Pharmaceutical Compounds
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Last Update: 02-04-2001