Prof. Anita R. Maguire

Department of Chemistry

Director, Analytical and Biological Chemistry Research Facility

University College Cork
Cork, Ireland
Tel: +353-21-4902125

Tel. (secretary) +353-21-4902167

Fax. +353-(0)21-4274097 (Departmental Office)

E-mail: a.maguire@ucc.ie       

  Professor of Pharmaceutical Chemistry 

Background

1985    B.Sc. (1st Hons.) at University College Cork

1989    Ph.D. at University College Cork (Prof. M.A. McKervey)

1989    Postdoctoral Associate, Facultes Universitaires, Namur, Belgium (Prof. A. Krief)

1990    Postdoctoral Fellow, University of Exeter, UK (Prof. S.M. Roberts)

1991    College Lecturer in Organic Chemistry, University College Cork

1998    Director, B.Sc. programme in The Chemistry of Pharmaceutical Compounds

2002    Director, Analytical and Biological Chemistry Research Facility

2002    Associate Professor of Organic Chemistry, University College Cork

2004    Professor of Pharmaceutical Chemistry

 

Research Interests and Activities

Link to Organic and Pharmaceutical Synthesis Research Team page

·        Novel synthetic methodology

- including the use of a-diazocarbonyl compounds and organosulfur compounds in synthesis

·        Asymmetric synthesis

- including asymmetric catalysis and application of biotransformations in organic synthesis

·        Synthesis of biologically active compounds

- current projects are targeted towards compounds with anti-viral and anti-cancer activity

·        Extensive interaction with the pharmaceutical industry, within Ireland and overseas

 

Administrative Experience

·        Member of National Research Support Fund Board from Jan.1999-Dec. 2001.

·        Member of  ICSTI from September 2000.

      Chairman, ICSTI Task Force on Embedding the PharmaChem Sector in Ireland 2001-3.

·        Member of IRCSET from June 2001.

·        Vice Chairman (1998- 1999), Chairman (1999-2000) of the EU COST (European Co-operation in the Field of Scientific and Technical Research) Management Committee for Action D12 concerning "Organic Transformations: Selective Processes and Asymmetric Catalysis".

Vice Chairman (2001 to date) D24 “Sustainable Chemical Processes: Stereoselective Transition Metal-Catalysed Reactions”.

Member of Management Committee (2002 to date) D28 “Natural Products as a Source for Discovery , Synthesis and Application of New Pharmaceuticals”.

·        Member of the Forfas Technology Foresight Chemical and Pharmaceutical Panel (1998).

 

 

Selected Publications

Excellent Stereocontrol in Intramolecular Buchner Cyclisations and Subsequent Cycloadditions; Stereospecific

Construction of Polycyclic Systems.

A.R. Maguire, N.R. Buckley, P. O’Leary, and G. Ferguson, Chem. Commun., 1996, 2595-6.

 

Asymmetric Reduction of 1-Methylsulfonylalkan-2-ones with Baker's Yeast.

A.R. Maguire and D.G. Lowney, J. Chem. Soc., Perkin Trans. 1, 1997, 235 - 8.

 

Selective Manganese-Mediated Transformations Using the Combination : KMnO4 / Me3SiCl.

I.E. Marko, P.R. Richardson, M. Bailey, A.R. Maguire and N. Coughlan, Tetrahedron Lett., 1997, 38, 2339-42.      

 

Enantioselective Introduction of a Benzenesulfonylmethyl Substituent at an Unactivated Carbon Atom via Chemoenzymatic

Methods.

A.R. Maguire and L.L. Kelleher, Tetrahedron Lett., 1997, 38, 7459 - 62.

 

Synthesis of a-Diazo-b-Oxo Sulfoxides

A.R. Maguire, P.G. Kelleher, G. Ferguson, and J.F. Gallagher, Tetrahedron Lett., 1998, 39, 2819-22.

 

Rhodium Catalysed Decomposition of a-Diazosulfoxides : Formation of a-Oxo Sulfines as Intermediates

A.R. Maguire, P.G. Kelleher and S.E. Lawrence, Tetrahedron Lett., 1998, 39, 3849-52.

 

Stereocontrol in the Intramolecular Buchner Reaction of Diazoketones

A.R. Maguire, N.R. Buckley, P. O’Leary, and G. Ferguson, J. Chem. Soc., Perkin Trans. 1 , 1998, 4077-91.           

 

Dynamic Kinetic Resolution in the Baker's Yeast Mediated Reduction of 2-Benzenesulfonylcycloalkanones

A.R. Maguire and N. O'Riordan, Tetrahedron Lett., 1999, 40, 9285-8.

 

Matrix Isolation and Photochemistry of a-Diazo Sulfoxides: Formation of an a-Oxo Sulfine as an Intermediate

W. Sander, A. Strehl, A.R. Maguire, S. Collins, and P.G. Kelleher, Eur. J. Org. Chem., 2000, 3329-3335.

 

Synthesis of Indomethacin Analogues for Evaluation as Moderators of MRP Activity

A.R. Maguire, S.J. Plunkett, S. Papot, M. Clynes, R. O’Connor and S. Touhey, Biorg. Med. Chem., 2001, 9, 745-762.

 

Enantioselective Synthesis of Sulindac   

A.R. Maguire, S. Papot, A. Ford, S. Touhey, R. O’Connor, and M. Clynes, Synlett, 2001, 41-4.

 

4-Ethynyl-1,2-methylenedioxybenzene at 150K

S.E. Lawrence, A.J. Blake, A.R. Maguire, and E.J.A. Moynihan, Acta Cryst C, 2001, 412-413.

 

Dynamic Equilibria in the Products of Intramolecular Buchner Additions of Diazoketones to Aryl Rings Bearing Methoxy

Substituents

Anita R. Maguire, Patrick O'Leary, Francis Harrington, Simon E. Lawrence and Alexander J. Blake, J. Org. Chem.,

2001,
66, 7166-7177.

 

New Methods for the Synthesis of N-Benzoylated Uridine and Thymidine Derivatives

Anita R. Maguire, Isabelle Hladezuk and Alan Ford, Carbohydrate Research, 2002, 337(4), 369-372.

 

Structure-Activity Relationship of Indomethacin Analogues for MRP-1, COX-1 and COX-2 Inhibition; Identification of

Novel Chemotherapeutic Drug Resistance Modulators

S. Touhey, R. O’ Connor, S.J. Plunkett, A.R. Maguire and M. Clynes, Eur. J. Cancer, 2002, 38(12), 1661-70.

 

Chemoenzymatic methods in the asymmetric synthesis of α-diazosulfoxides

Anita R. Maguire, Stuart G. Collins and Alan Ford, ARKIVOC, 2003, Part (vii), 96-109.

 

 

B.Sc. in Chemistry of Pharmaceutical Compounds

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Last Update: 02-04-2001